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Allopurinol (allopurinol) is structured around Xanthine compounds
(seventh in the purine ring is c, eighth, n), the inhibition of
Xanthine oxidase has a strong, often used to treat gout.
This product is white or almost white crystalline powder almost
odourless. This product is very slightly dissolve in water or
ethanol, insoluble in chloroform or ether; in a solution of sodium
hydroxide or potassium hydroxide soluble.
1. Thiopurine co-therapy
Allopurinol CAS 315-30-0 can cause severe pancytopenia if given
with full-dose mercaptopurine or its pro-drug azathioprine, due to
the inhibition of xanthine oxidase that metabolizes mercaptopurine.
For this reason, allopurinol CAS 315-30-0 has been strongly
contraindicated during thiopurine therapy in the past. However, in
recent years the use of allopurinol cas 315-30-0 in combination
with azathioprine or mercaptopurine has been revived. First,
allopurinol cas 315-30-0 was shown that an azathioprine/allopurinol
combination significantly improved renal transplant graft survival.
More recently, allopurinol cas 315-30-0 was discovered that this
co-therapy greatly improves the outcome for patients that do not
respond to thiopurine monotherapy when treating inflammatory bowel
disease (IBD), specifically Crohn's disease.
2. Reperfusion injury
Other established indications for allopurinol therapy include
ischemic reperfusion injury, kidney stones with a uric acid
component (uric acid nephrolithiasis), and protozoal infections
3. Renal disease, Heart failure and Angina
Allopurinol can be used in patients with poor kidney function, but
it may also help them. A study of allopurinol use in patients with
chronic kidney disease suggested that "Allopurinol decreases
C-reactive protein and slows down the progression of renal disease
in patients with chronic kidney disease. In addition, allopurinol
reduces cardiovascular and hospitalization risk in these subjects."
Allopurinol CAS 315-30-0 is used as an add-on drug for refractory
epilepsy, because it is an adenosine agonist, which inhibits
glutamine release from excitatory neurons, but does not change the
plasma concentration of other epilepsy drugs.
5. Blood pressure
Allopurinol CAS 315-30-0 can decrease blood pressure reducing
|CAS no.||315-30-0||Outer packing||1KG/foil bag|
|Storage||Store in a well-closed container away from moisture|
|Items of analysis||Specification||Results|
|Description||White or almost white powder||White powder|
|Solubility||Very slightly soluble in water and alcohol practically insoluble in
ether.it dissolves in dilute solutions of the alkali hydroxide.||Complies|
|Identification||Infrared absorption(197K),The IR absorption spectrum of sample
exhibits the same spectrum as Reference Standard||Complies|
|Loss on drying||≤0.5%||0.12%|
|Related substances by HPLC||Impurity A≤0.2%||0.03%|
|Impurity B≤0.2%||Not detected|
|Impurity C≤0.2%||Not detected|
|Impurity F≤0.2%||Not detected|
|Any individual unspecified impurity≤0.1%||0.02%|
|Limit of hydrazine||≤10ppm||Complies|
|Conclusion||Conforms to USP38 standard|