Top Quality HGH human growth hormone HGH 191aa Muscle growth
Somatropin/HGH Fragment 176-191
White Lyophilized Powder
Place of Origin:
USP EP JP etc.
Growth hormone (GH), also known as somatotropin (or as human growth
hormone [hGH or HGH] in its human form), is a peptide hormone that
stimulates growth, cell reproduction, and cell regeneration in
humans and other animals. It is thus important in human
development. It is a type of mitogen which is specific only to
certain kinds of cells. Growth hormone is a 191-amino acid,
single-chain polypeptide that is synthesized, stored, and secreted
by somatotropic cells within the lateral wings of the anterior
Product function :
Increased height during childhood is the most widely known effect
of GH. Height appears to be stimulated by at least two
mechanisms:Effects of growth hormone on the tissues of the body can
generally be described as anabolic (building up). Like most other
protein hormones, GH acts by interacting with a specific receptor
on the surface of cells.
1. Because polypeptide hormones are not fat-soluble, they cannot
penetrate cell membranes. Thus, GH exerts some of its effects by
binding to receptors on target cells, where it activates the
MAPK/ERK pathway. Through this mechanism GH directly stimulates
division and multiplication of chondrocytes of cartilage.
2. GH also stimulates, through the JAK-STAT signaling pathway, the
production of insulin-like growth factor 1(IGF-1, formerly known as
somatomedin C), a hormone homologous to proinsulin. The liver is a
major target organ of GH for this process and is the principal site
of IGF-1 production. IGF-1 has growth-stimulating effects on a wide
variety of tissues. Additional IGF-1 is generated within target
tissues, making it what appears to be both an endocrine and an
autocrine/paracrine hormone. IGF-1 also has stimulatory effects
onosteoblast and chondrocyte activity to promote bone growth.
In addition to increasing height in children and adolescents,
growth hormone has many other effects on the body:
·Increases calcium retention, and strengthens and increases the
mineralization of bone
· Increases muscle mass through sarcomere hypertrophy
· Promotes lipolysis
· Increases protein synthesis
·Stimulates the growth of all internal organs excluding the brain
· Plays a role in homeostasis
· Reduces liver uptake of glucose
· Promotes gluconeogenesis in the liver
· Contributes to the maintenance and function of pancreatic islets
·Stimulates the immune system
·Increases deiodination of T4 to T3
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