Theophylline Raw Powder Methylxanthine Used In The Treatment Of
COPD CAS 58-55-9
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What is theophylline?
Theophylline is a "methylxanthine." This is a chemical that relaxes
smooth muscle around the airways of the lungs. It also may act in
other ways to help open the airways. There are other
methylxanthines such as caffeine and theobromine. They are found in
coffee, tea, and chocolate/cocoa, but they are not as strong as
Theophyline For COPD
Theophyline is a bronchodilator that's been used in the treatment
of COPD for more than seven decades. It is used to treat wheezing
or shortness of breath caused by asthma, bronchitis, emphysema and
other breathing disorders. It works by relaxing the muscles in the
lungs and chest, making it easier to breathe.
How does theophylline for COPD work?
Theophyline is part of the methylxanthines class. It has two
different mechanisms of action in people with reversible lung
obstruction: as a bronchodilator, it causes smooth muscle
relaxation. Its non-bronchodilator effects suppress the response of
the airways to stimuli.
Its mechanism of action is not fully known, although animal studies
suggest that the bronchodilation involves the inhibition of two
phosphodiesteraseenzymes(PDE ll and PDE IV) while the suppressive
effects are probably due to different mechanisms that do not
involve these enzymes.
Theophylline also increases the force of contraction of
diaphragmatic muscles, probably due to the increase of
intracellular calcium through an adenosine-mediated channel. It
hasn't been used as often as it was in the past as better-tolerated
and more effective bronchodilators have come on the market.
Studies of theophylline
Studies of people with COPD have shown that theophylline decreases
dyspnea, air trapping, and breathing difficulties, and increases
diaphragmatic muscle contraction force.
What are possible theophylline side effects?
The side effects include:
- fast, pounding, or irregular heart beat
- stomach ache
- loss of appetite
If I have side effects early on, when can I expect side effects to
Many people do not have side effects. If you have side effects
early on, they often disappear after the first week of treatment.
If side effects persist, or if they make you uncomfortable, notify
your doctor. Other medicines and illnesses also cause these
symptoms. If you experience side effects at the start of therapy,
the first four days can be the worst, with side effects improving
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|Synonyms:||High purity Theophylline CAS NO.58-55-9;Caffeine Impurity
1(Caffeine EP Impurity A);Theophylline Anhydrous
Impurity 3(Pentoxifylline EP Impurity C);1H-Purine-2,6-dione,