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CAS No.: 51-05-8
MF: C13H20N2O2. HCl
Appearance: White crystal to powder
Package: 25kg cardboard drum or as customer's requirement
Standard: BP/ USP
Procaine is a kind of local anesthetics. With low toxicity but
quick and safe effects, procaine is suitable for local anesthesia,
applied to the eye, ear, nose, teeth and other department
operation, used for infiltration anesthesia, anesthesia and closed
therapy supervisor. Procaine is also used in the production of
procaine penicillin.Procaine causes loss of feeling (numbness) of
skin and mucous membranes.Procaine is used as an injection during
surgery and other medical and dental procedures.
Hormones and Regulation of Endocrine Function of Drug, Regulating
Water and Salt, Electrolyte and Acid-Base Balance of Medicine,
Anesthetic and Adjuvant, Blood System Agents, Drug Treatment of
Mental Disorder, Visceral System Medication, Cardiovascular Agents,
Respiratory System Agents, Disinfectant and Preservatives.
Procaine HCl is a local anesthetic drug of the amino ester group.
It is used primarily to reduce the pain of intramuscular injection
of penicillin, and it is also used in dentistry. Owing to the
ubiquity of the trade name Novocain, in some regions procaine is
referred to generically as novocaine. It acts mainly by being a
sodium channel blocker.Today it is used therapeutically in some
countries due to its sympatholytic, anti-inflammatory, perfusion
enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional
analgesia and anesthesia by local infiltration and peripheral nerve
Application of procaine leads to the depression of neuronal
activity. The depression causes the nervous system to become
hypersensitive producing restlessness and shaking, leading to minor
to severe convulsions. Studies on animals have shown the use of
procaine led to the increase of dopamine and serotonin levels in
the brain.Other issues may occur because of varying individual
tolerance to procaine dosage. Nervousness and dizziness can arise
from the excitation of the central nervous system, which may lead
to respiratory failure if overdosed. Procaine may also induce
weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals
to have problems with breathing, rashes, and swelling. Allergic
reactions to procaine are usually not in response to procaine
itself, but to its metabolite PABA. About one in 3000 people have
an atypical form of pseudocholinesterase, which
does not hydrolyze ester anesthetics such as procaine, resulting in
a prolonged period of high levels of the anesthetic in the blood
and increased toxicity
|Chemische Bezeichnung oder Material||Procaine hydrochloride|
|Verlust bei Trocknung||0.5% max. (1 g, 105°C)|
|Farbe||Colorless to White|
|Schmelzpunkt.||154.0°C to 158.0°C|
|pH.||5 to 6.5 (2% w/v aq. soln.)|
|Merck Index||15, 7875|
|Synonym||procaine hydrochloride, procaine hcl, gerovital h3, 2-diethylamino
ethyl 4-aminobenzoate hydrochloride, geriocaine, atoxicocaine,
chlorocaine, neotonocaine, aminocaine, anadolor|
|Informationen zur Löslichkeit||Solubility in water: soluble. Other solubilities: soluble in
chloroform, practically insoluble in ether|
|IUPAC Name||2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride|
|Molecular Weight (g/mol)||272.773|
|Physikalische Form||Crystals or Crystalline Powder|
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