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Pain Killer Pramoxine Hydrochloride Local Anesthetic Drugs Raw Material Tronothane Hydrochloride CAS 637-58-1

Categories Local Anaesthesia Drugs
Brand Name: LSW
Model Number: 637-58-1
Certification: ISO9001,BRC,KOSHER
Place of Origin: CN
MOQ: 10g
Price: Negotiation
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 5000kg/month
Delivery Time: 5-8 working days
Packaging Details: discreet package
CAS: 637-58-1
MF: C17H28ClNO3
MW: 329.8621
Einecs No: 211-293-1
Purity: 99%
Appearance: white or almost white crystalline powder
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Pain Killer Pramoxine Hydrochloride Local Anesthetic Drugs Raw Material Tronothane Hydrochloride CAS 637-58-1


Pain Killer Pramoxine Hydrochloride Local Anesthetic Drugs Raw Material Tronothane Hydrochloride CAS 637-58-1



Basic Info.


Product Name: Pramoxine Hydrochloride
Synonyms: 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam;PRAMOXINE HCL;PRAMOXINE HYDROCHLORIDE;PRAXOMINE HYDROCHLORIDE;TRONOTHANE HYDROCHLORIDE
CAS: 637-58-1
EINECS Number: 211-293-1
Formula: C17H28ClNO3
MW: 329.8621
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 °C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Assay:99%
Appearance: white or almost white crystalline powder
Uses:Local anesthetics,
slows growth of unwanted facial hair


Description:


Pramoxine Hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property.Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.


Pramoxine is used to temporarily relieve itching and pain caused by minor skin irritation such as minor burns/cuts/scrapes, sunburn, eczema, insect bites, cold sores, or rashes from poison ivy, poison oak, or poison sumac. Some products containing pramoxine are also used to temporarily relieve the itching and discomfort from hemorrhoids and certain other problems of the genital/anal area (such as anal fissures, itching around the vagina/rectum).


Pramoxine hcl,Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.
Pramoxine hcl,Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.


Application:


Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.


Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.



COA:


Product
pramoxine Hcl

Tests

Results

Specifications

Description

white,crystalline powder

white to almost white,crystalline powder

Solubility

Complies

Freely soluble in water and in alcohol ,soluble in chloroform,very slightly soluble in ether

PH

4.37

About 4.5
IdentifIcation
Complies

A:By IR, To match with working standard

Complies

B:By HPLC, To match with working standard

Complies

C: A solution responds to the test for Chloride

Melting point

172.6ºC~173.5ºC

170ºC~174ºC

Loss on drying

0.18%

≤1.0%

Residue on ignition

0.03%

≤0.1%
Residual Solvents
Not detected

Toluene Not more than0.089%

Not detected

Ethanol Not more than0.5%

0.003%

Petroleum ether Not more than0.5%
0.009%
Acetone Not more than0.5%

0.006%

Methanol Not more than0.3%

Assay

99.96%

98.0%-102.0% (on the anhydrous basis)

Conclusion: Conforms to USP36

Pramoxine Hydrochloride Fuction:


Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.


Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.

Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.


Pramoxine HCL Dosage:


Pramoxine hydrochloride cream USP can be used by adults and adolescents as needed three to four times per day. The same dosing instructions can also be followed in the use of pramoxine hydrochloride lotion, pramoxine hydrochloride and menthol gel as well as pramoxine hydrochloride and menthol lotion. Proper dosing for pediatric use in children younger than two years old has not been established. Pramoxine should not be applied across large areas of the body and should not be used for extended periods of time as this may increase the risk of toxicity and systemic absorption.


Usages:

Pramoxinehcl,Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
Pramoxine hcl, Muscle relaxant (smooth)and slows growth of unwanted facial hair.

Pramoxine hydrochloride cream USP can be used by adults and adolescents as needed three to four times per day. The same dosing instructions can also be followed in the use of pramoxine hydrochloride lotion, pramoxine hydrochloride and menthol gel as well as pramoxine hydrochloride and menthol lotion. Proper dosing for pediatric use in children younger than two years old has not been established. Pramoxine should not be applied across large areas of the body and should not be used for extended periods of time as this may increase the risk of toxicity and systemic absorption.


Where Should Keep Medicine?


Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.


Related Products:
BenzocaineCAS:94-09-7
Benzocaine hydrochlorideCAS:23239-88-5
Tetracaine hydrochlorideCAS:136-47-0
ProcaineCAS:136-47-0
TetracaineCAS:94-24-6
Pramoxine HydrochlorideCAS:637-58-1
Procaine HClCAS:51-05-8
LidocaineCAS:137-58-6
Dibucaine hydrochlorideCAS:61-12-1
PrilocaineCAS:721-50-6
Propitocaine hydrochlorideCAS:1786-81-8
Proparacaine hydrochlorideCAS:5875-06-9
Lidocaine hydrochlorideCAS:73-78-9
Articaine hydrochlorideCAS:23964-57-0
Levobupivacaine hydrochlorideCAS:27262-48-2
Ropivacaine hydrochlorideCAS:132112-35-7
BupivacaineCAS:2180-92-9
Bupivacaine hydrochlorideCAS:14252-80-3
Pramoxine hydrochloride637-58-1
Larocaine HCl553-63-9

Competitive Advantage:


1. Rich experiences.
Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on,and we have got very good feedback from our customers, we had established a long friendly relations
Payment method: T/T, Western union, Moneygram


2. Discreet package.
The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .


3. Top quality.
High quality guarenteed, once any problem is found, the package would be reshipped for you


4. Security Shipping:
Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.


5. We have stock, so we can delivery quickly at the very day when receive the payment.


6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most sincere services as possible as we can.


7. High quality, best price, first-class service, high successful delivery rate .A discount would be given when you make a large order.


If you have any questions, pls feel free to contact me:

Email:pennsy (at) chembj (dot) com Whatsapp:+8618872220800

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