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CAS 6108-05-0 White Pharmaceuticals Raw Materials powder Lidocaine Hydrochloride

Categories Pharmaceuticals Raw Materials
Brand Name: Bodybiological
Model Number: CAS: 6108-05-0
Certification: ISO9001,SGS
Place of Origin: China, Hubei
MOQ: 1kg
Price: USD10
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg/month
Delivery Time: Within 24 hours after the payment
Packaging Details: 25kg/drum
Packing: 25kg/drum
Purity: 99.5%
Policy: Resend policy
Shipping way: FEDEX,DHL,TNT,HK EMS, Airmail...
Appearance: White crystalline powder
Molecular Formula: C14H22N2O
Delivery time: within 24 hours upon receipt of payment
Product name: Lidocaine HCL
Usage: Topically used to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery
CAS: 6108-05-0
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CAS 6108-05-0 White Pharmaceuticals Raw Materials powder Lidocaine Hydrochloride

White Crystalline Pharmaceuticals Raw Powder Lidocaine Hydrochloride for Sale


Quick details:


Lidocaine Base CAS: 137-58-6
Product Name: Lidocaine Base
Synonyms: 2-(Diethylamino)-N-(2, 6-dimethylphenyl)-acetamide; Lignocaine; 2-diethylaminoacet-2, 6-xylidide; Lidocaine; Xylocaine; N-(2, 6-dimethylphenyl)-N~2~, N~2~-diethylglycinamide; 2-[(2, 6-dimethylphenyl)amino]-N, N-diethyl-2-oxoethanaminium
CAS Registry Number: 137-58-6
Assays: 99%
Packaging: 25kg/drum
Molecular Formula: C14H23N2O
Molecular Weight: 235.3447
EINECS: 205-302-8
Appearance: White Crystalline Powder


Description:


Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Applications:


  • This medication is used on the skin to stop itching and pain from certain skin conditions (e.g., scrapes, minor burns, eczema, insect bites) and to treat minor discomfort and itching caused by hemorrhoids and certain other problems of the genital/anal area (e.g., anal fissures, itching around the vagina/rectum). Some forms of this medication are also used to decrease discomfort or pain during certain medical procedures/exams (e.g., sigmoidoscopy, cystoscopy). Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.
  • Local anesthesic;Na+ channel blocker
  • Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

Drug Class And Mechanism:


Lidocaine is an antiarrhythmic agent (affects heart rhythm) as well as a local anesthetic (amide type). It is similar to bupivacaine and procaine. Lidocaine, like other local anesthetics causes a loss of sensation by reducing the flow of sodium in and out nerves to decrease the initiation and transfer of nerve signals. Compared to procaine, lidocaine has a more rapid onset, longer duration of action, and more potent activity. Lidocaine works as an antiarrhythmic by also decreasing conduction of electrical signals in damaged (ischemic) heart tissue. Lidocaine was approved by the FDA in November 1948.


Pharmacodynamics:


(1) Anaesthesia


Lidocaine alters signal conduction in neurons by blocking the fast voltage-gated Na+ channels in the neuronal cell membrane responsible for signal propagation. With sufficient blockage, the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain, but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations also affect other modalities of neuron signaling.


(2) Antiarrhythmic


The same principle applies for this drug's actions in the heart. Blocking sodium channels in the conduction system, as well as the muscle cells of the heart, raises the depolarization threshold, making the heart less likely to initiate or conduct early action potentials that may cause an arrhythmia.


COA :


Product NameLidocaine
Other Name2-(Diethylamino)-N-(2,6-dimethylphenyl) acetamide
Assay (%)≥99.5OdorCharacteristic
ColorWhite crystalline powderCas No.137-58-6
Molecular FormulaC14H22N2OMolecular Weight234.34
StandardUSP30
Main functions are as follows:
Function1. Local anesthetic.
2. Treating Epilepsy.
3. Treating Asthma.
ApplicationsMain applications are as follows:
Applied in pharmaceuticalfields.
Packing25kg/drum
StorageStore in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Items TestedSpecificationBP2007Result
CharactersWhite or slightly yellow crystal powder with characteristic odorWhite crystal powder with weak odor
Melting pointMelting point: 66 degree to 70 degree66.6 degree-68.5 degree
IdentificationBCDEConforms
Comply with the requirement
Appearance of solutionClear and colorlessConforms
WaterNot more than 0.5%0.30%
SulphateNot more than0. 1%Conforms
ChlorideNot more than 0. 0035%0.00%
Heavy MetalsNot more than 0.002%0.00%
Residue on IgnitionNot more than 0.1%0.02%
ImpurityNot more than 0.01%Conforms
(26-dimethylaniline content)
Assay (HPLC)99.0%-101.0%99.60%
ConclusionConforms BP2007

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