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Tretinoin Pharmaceutical Raw Material Vitamin Ascorbic Acid Yellow Powder

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: CAS: 302-79-4
Certification: GMP, SGS , ISO 9001:2008 , KOSHER
Place of Origin: China
MOQ: 100g
Price: Contact Us
Payment Terms: Western Union, MoneyGram, Bank Transfer, Bitcoin
Supply Ability: 4000 KG/Month
Delivery Time: Within 7 Working Days
Packaging Details: Stealth And Discreet Packaging
Product Name: Tretinoin
Synonyms: VITAMIN A ACID
MF: C20H28O2
MW: 300.44
EINECS: 206-129-0
Melting Point: 180-181 °C
Storage temp: 2-8°C
Water Solubility: insoluble
Appearance: Yellow powder
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Tretinoin Pharmaceutical Raw Material Vitamin Ascorbic Acid Yellow Powder


Important Pharmaceutical Raw Material Tretinoin (VITAMIN A ACID) Yellow Powder



Description:


1. Tretinoin is commonly used in dermatology drugs, which is the department of vitamin A


(Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial


metabolism, can promote epithelial cell proliferation and updates, and can inhibit the proliferation


and differentiation of keratinocytes, so hyperkeratosis can be back to normal.


2. Therefore many complete or incomplete keratosis, hyperkeratosis of diseases have a certain


therapeutic effect, treat a variety of skin diseases. The use of the drug can penetrate topical skin


quickly, enable significantly increased epithelial cell turnover. This class of drugs has strong and


rapid inhibition on the secretion of the sebaceous glands, can reduce sebum secretion. In


addition, the product also has anti-tumor, promote wound healing and anti-inflammatory effects.


3. It is a yellow needle crystal, with a similar smell of vitamin acetate. Soluble in methanol, ethanol,


acetone, also in vegetable oil and fatty. In case of light, it is thermal instability, suck up moisture in


the air, polymerization and metamorphism in water. The melting point of all trans-vitamin A acid is


182 ~ 180°C, the melting range of which is mixed with a small amount of isomers is 170 ~ 190°C.


4. This product can induce epidermal hyperplasia, and improve the granular layer and the cell


layer thickness.It can influence the silk protein process and the formation of cross-linked film and


promote the differentiation of epidermal granular layer cells in the late stage of the differentiation


of the epidermal cells by affecting K10, K1 keratin solution.


Usage:

Used in abnormal acne, ichthyosis and abnormal type of psoriasis. For the treatment of acne


vulgaris, psoriasis, ichthyosis, lichen planus, Mao Fahong rosea, follicular keratosis, squamous


cell carcinoma and melanoma, disease.


Pharmacology: Epidermal keratinocytes, dermal melanin cells and fibroblasts are the target cells


of A retinoic acid important. A retinoic acid can affect the formation of melanin melanin cells, its


role is more than point, has inhibitory effect on tyrosine hydroxylase, Doba oxidase and two


hydroxyindole oxidase three catalytic activity, thereby reducing the formation of melanin, reduce


skin pigmentation.


Function:

1. Used for usual acne, lichen planus, white spot, hair red pityriasis and facial pityriasis simplex

2. Also can be used as an auxiliary therapy for psoriasis.

3. Can also be used in the treatment of multiple verruca vulgaris, and abnormal keratinization of


various skin diseases such as ichthyosis, hair follicle keratinization disorder

4. For cancer prevention and treatment of precancerous lesions, Such as white spot of the oral


mucosa, laryngeal papilloma, stunting disease

5. Used for skin malignant tumor such as squamous cell carcinomas and basal cell carcinoma,


mycosis enzyme disease

6. For acute early young granulocyte leukemia.


Lab Test Result:


Items

Specification

Results

Loss on drying

≤0.5%

0.02%

Residue on ignition≤0.1%0.04%
Heavy metals≤0.002%<0.002%
Assay98% - 100%99.35%

Related substances(Reporting threshold 0.05%)

Isotretinoin≤5.0%<0.05%
Impurity G≤0.2%<0.05%
Single unknown impurity≤0.10%RRT≈0.91<0.05%
Total impurities(Except Isotretinoin)≤0.5%0.01%

Residual solvents

Acetaldehyde≤15ppm<15ppm
Ethyl acetate≤5000ppm865ppm

Microbiological limit tests

Bacteria≤100CFU/g<20CFU/g
Molds and yeasts≤100CFU/g<20CFU/g
Staphylococcus aureus and P.aeruginosaAbsentAbsent



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