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USA FDA Approved Sleep Promoting Drug Tasimelteon Raw Powder CAS 609799-22-6

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: CAS: 609799-22-6
Certification: GMP , ISO 9001:2008
Place of Origin: CHINA
MOQ: 10g
Price: Contact Us
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 400 KG/Month
Delivery Time: Within 7 Working Days
Packaging Details: Stealth And Discreet Packaging
Product Name: Tasimelteon
Other Name: BMS 214778; MA 1; VEC 162
MF: C15H19NO2
MW: 245.32
Density: 1.145
Appearance: White Powder
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USA FDA Approved Sleep Promoting Drug Tasimelteon Raw Powder CAS 609799-22-6


USA FDA Approved Sleep Promoting Drug Tasimelteon Raw Powder



Description:


Tasimelteon is a melatonin receptor agonist. Because of the high density of melatonin receptors


in the circadian pacemaker, the suprachiasmatic nucleus, melatonergic actions can phase-shift


circadian rhythms and promote sleep. Tasimelteon was effective in reducing sleep onset latency


(in phase II and III clinical trials) and in resetting the circadian melatonin rhythm (in phase II trials),


which indicated its potential suitability as treatment for jet lag, shift work and circadian rhythm


sleep disorders. Statistically significant improvements in sleep maintenance have also been


observed with the drug. Tasimelteon has been claimed to be useful in the treatment of


depression, and preclinical evidence in this respect is to be confirmed in a phase II clinical trial,


which was ready to be initiated at the time of publication. It is plausible that the drug may be


effective in the treatment of depressive disorders, at least those that are related to circadian


dysfunction, and that it may attenuate sleep problems in depressed patients of different subtypes.


A general suitability in mitigating other symptoms of major depressive disorder cannot be


deduced from the actions of tasimelteon via the melatonin receptors MT1 and MT2. The drug is


well tolerated, does not induce impairment of next-day functioning or dependence, and seems to


be safe in short-term treatment; however, toxicological data would be required for assessing its


long-term safety.




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