Coluracetam (BCI-540) is a nootropic drug of the racetam
family.Coluracetam (formerly known as MKC-231) was initially
developed and tested by the Mitsubishi Tanabe Pharma Corporation
for Alzheimer's disease. Coluracetam enhances high-affinity choline
uptake (HACU) which is the rate-limiting step of acetylcholine
(ACh) synthesis, and is the only known choline uptake enhancer to
currently exist. Studies have shown Coluracetam to improve learning
impairment on a single oral dose given to rats which have been
exposed to cholinergic neurotoxins. Subsequent studies have shown
that it may induce long-lasting procognitive effects by changing
the choline transporter regulation system.
After the drug failed to reach endpoints in its clinical trials it
was in-licensed by BrainCells Inc for investigations into major
depression disorder (MDD), after being awarded a "Qualifying
Therapeutic Discovery Program Grant" by the state of California.
Findings from its Phase 2a clinical trials have suggested that it
would be an ideal medication for co-morbid MDD with generalized
anxiety disorder (GAD). BrainCells Inc is currently out-licensing
the drug for this purpose. It may also have potential use in
prevention and treatment of ischemic retinopathy and retinal and
optic nerve injury.
Rat studies have shown that Coluracetam is helpful in reducing the
effects of learning deficits. Not only did Coluracetam reduce these
effects, but Coluracetam also did not have any of the normally
expected side effects. This product is also considered to have
great potential as a casual mood enhancer and a powerful memory
booster. There is even evidence to suggest that the positive
effects on the brain are semi-permanent Users also report a rather
wide range of Coluracetam benefits. This includes enhanced
concentration and speed of cognition. Coluracetam also helps with
both short and medium term memory. There are also a number of
reports of being able to study and focus more easily while taking
this nootropic. Coluracetam also seems to have a bit of a stimulant
effect. It should help to shake off any of the morning dreariness
if taken upon waking and it may produce a nice, comfortable energy
boost that can last well into the day. A number of users have
reported that this is able to help them improve their motivation
and ability to get things done. Another interesting effect is the
apparent enhancement of sounds and colors. This can be compared to
turning up the brightness on a TV or computer screen, with sounds
become fuller and richer.
Coluracetam enhances high-affinity choline uptake (HACU) which is
the rate-limiting step of acetylcholine (ACh) synthesis, and is the
only known choline uptake enhancer to currently exist. Studies have
shown Coluracetam to improve learning impairment on a single oral
dose given to rats which have been exposed to cholinergic
neurotoxins. Subsequent studies have shown that it may induce
long-lasting procognitive effects by changing the choline
transporter regulation system.
Memory and Learning
Coluracetam is shown to improve cognitive function and memory in
rats, and in theory, the same results are expected in human beings.
A study conducted by BrainCells Inc, showed a memory improvement in
rats who were given substance AF64A (a neuron-specific neurotoxin)
for 8 days along with Coluracetam in 3mg doses. These rats were put
through the standardized Morris Water Maze to mark their ability to
get through it, and even up to 72 hours after the last 8mg dose,
they were still able to. Another key finding of this study was that
the results were still apparent 3 days after the last dose, even
though the serum concentration of Coluracetam was negligible.
Depression and Anxiety
BrainCells Inc, found that a dosage of 240mg (split into three
daily doses of 80mg) was useful in treating major depression
co-morbid with GAD (generalized anxiety disorder). However, the
differences were most pronounced in those who didn't find relief in
using standard antidepressants. After one dose, there were no
noticeable differences, but after 2 doses at 80mg, 36% had improved
scores during a depression assessment test.
Coluracetam has been associated with optic benefits such as
enhanced color vision, recognition and vividness. Although there
isn't any conclusive evidence to support the mechanisms behind this
benefit, experts believe that Coluracetam works in the part of the
brain that runs visual processes.