Synonyms:2,2-dichloro-n- (1- (fluoromethyl) -2-hydroxy-2- (4-
(methylsulfonyl) phenyl) ethyl; 4- (2- (1-fluoro-1-hydroxypropyl)
-benzenesulfonicaci; FLORFENICOL; AQUAFEN; 2,2-dichloro-n - [(1r,
2s) -3-fluoro-1-hydroxy- Methyl-sulfonylphenyl) propan-2-yl]
acetamide; NUFLOR; [r- (r *, r *)] - n- [1- (fluoromethyl)
-2-hydroxy-2- (4- -2,2-dichloroacetamide
Molecular Weight: 358.21
Appearance: white powder
Usage:Broad spectrum Antimicrobial Drugs
Florfenicol is a commonly used veterinary antibiotics,
antibacterial spectrum, antibacterial effect, the minimum
inhibitory concentration (MIC) is low, antibacterial effect is
chloramphenicol, thiamphenicol 15-20 times, feed 60 minutes after
administration, the concentration of drugs in the organization can
reach the peak, can quickly control the disease, high security,
non-toxic, no residue and other characteristics, no potential for
aplastic anemia hidden, suitable for large-scale large-scale farms,
For the treatment of Pasteurella and Haemophilus caused by bovine
respiratory disease. On the bacilli caused by beef rot disease has
a better effect. Also used for sensitive bacteria caused by pig,
chicken infectious diseases and fish bacterial disease.
Florfenicol is not easy to produce resistance: because the use of
fluorine atoms to replace the molecular structure of thiamphenicol
hydroxyl, effectively solve the chloramphenicol, thiamphenicol
resistance problems. Thiamphenicol, chloramphenicol, amoxicillin,
quinolone-resistant strains are still sensitive to this product.
Because chloramphenicol has a serious lead to aplastic anemia and
immunosuppression and other adverse reactions, it is prohibited in
the use of food animal production. Studies have shown that:
chloramphenicol chemical structure caused by aplastic anemia is the
main group of aromatic ring on the bit nitro. The florfenicol is
CH3SO4 replaced NO2 group, so that the chemical structure has
changed, it is used in animals do not produce aplastic anemia
adverse reactions. As a result, more than a dozen countries in
Japan, Mexico and China have been approved for use.
Florfenicol is characterized by extensive antimicrobial spectrum,
resistance to Salmonella, Escherichia coli, Proteus, Haemophilus,
Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae,
Streptococcus suis, Pasteurella multocida, Bronchus ,
Staphylococcus aureus are sensitive. The drug is easy to absorb,
widely distributed in the body, for the quick, long-acting
formulations, no potential for aplastic anemia hidden, security is
better. In addition, the price is moderate, than other drugs to
prevent respiratory diseases such as tiamulin (branch of the
original net), tilmicosin, azithromycin and so cheap, the cost of
medication easy for users to accept. Because of these
characteristics, domestic fluorobenicol has been widely used, as
the current prevention and treatment of livestock and respiratory
tract and gastrointestinal bacterial infection of choice drug.
Florfenicol should not be combined with quinolones, penicillins,
cephalosporins, and should not be combined with ampicillin,
sulfonamides, furan drugs.
Florfenicol can strongly interfere with bacterial protein
synthesis, rapid absorption, widely distributed in vivo, long
half-life, no risk of side effects, not easy to produce resistance,
no residue, no cross-resistance.
Florfenicol can be used for livestock and aquatic animals, systemic
infection treatment, respiratory infections and intestinal
Poultry: E. coli, salmonellosis, infectious rhinitis, chronic
respiratory disease, duck plague and other sensitive bacteria
caused by mixed infection.
Animals: pig, cattle, sheep and other infectious pleurisy, asthma,
streptococcal disease, E. coli disease, salmonellosis, infectious
pleural pneumonia, asthma, piglet paratyphoid, yellow and white
diarrhea, edema disease, atrophic rhinitis, Epidemic, piglets red
and white diarrhea, no milk syndrome and other mixed infections.
Crabs: appendage ulcer disease, yellow gills, rotten gills, red
legs, inflammation and red body syndrome.
Taurus: red neck disease, furuncle disease, perforation disease,
rot skin disease, enteritis, mumps bacterial sepsis and so on.
Frogs: cataract syndrome, ascites, sepsis, enteritis and so on.
Fish: enteritis, ascites, vibriosis, Edwardsiosis and so on.
Eel: deodorant sepsis (unique efficacy), Edwardsiosis, red skin
disease, enteritis and so on.
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