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Emulsifier Pharmaceutical Excipients , Vitamin E TPGS Solubilizing Agent

Categories Pharmaceutical Excipients
Brand Name: Jason
Place of Origin: China
MOQ: negotiable
Price: negotiable
Supply Ability: 5tons/month
Packaging Details: 25kgs/drum
Certification: Kosher, ISO9001:2008
Appearance: White waxy solid
Application: Solubilizer, Emulsifier,Absorption & Bioavailability Enhancer of difficult to absorb lipophilic compounds,Carrier
Purity: Not less than 99.5%
Content of Ve: Not less than 250mg/g
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Emulsifier Pharmaceutical Excipients , Vitamin E TPGS Solubilizing Agent

Vitamin E TPGS , Emulsifyer , Solubilizing Agent


Introduction

d-α-Tocopheryl polyethylene glycol 1000 succinate (simply TPGS or Vitamin E TPGS) is formed by the esterification of Vitamin E succinate with polyethylene glycol 1000. As novel nonionic surfactant, it exhibits amphipathic properties and can form stable micelles in aqueous vehicles at concentration as low as 0.02 wt%.


Application

It has been widely investigated for its emulsifying, dispersing, gelling, and solubilizing effects on poorly water-soluble drugs. It can also act as a P-glycoprotein (P-gp) inhibitor and has been served as an excipient for overcoming multidrug resistance (MDR) and for increasing the oral bioavailability of many anticancer drugs. Since TPGS has been approved by FDA as a safe pharmaceutic adjuvant, many TPGS-based drug delivery systems (DDS) have been developed.


Specification

CAS NO.9002-96-4
ItemSpecification
Appearancewhite to brownish waxy solid
Purity by HPLCNot less than 99.5%
OdorNearly odorless
Acidity[mg KOH/g]Not more than 1.5
Content of VENot less than 250mg/g
Solubility in water20g sample can be dissolved in 80ml boiling water

Other information

Shelf life :at least 2 years sealed in original sealed container

Country of origin : China

Standard : In house standard

Package size :25kgs/drum

Storage : Keep tightly closed in a dry and cool place. Do not expose to excessive heat or cold

Product Tags:

excipients in drugs

  

vitamin e tpgs

  
Quality Emulsifier Pharmaceutical Excipients , Vitamin E TPGS Solubilizing Agent for sale
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