Pharmaceutical Raw Materials Respiratory System Drugs Roflumilast
for COPD CAS:162401-32-3
9302-107;BY 217;BYK 20869;Daxas;Roflumilast /
storage temp. Refrigerator
Chemical Properties Crystallin Solid
Usage Selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic;
in treatment of chronic obstructive pulmonary disease
Package: 1KG foil bag; 25Kg drum
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its
selective inhibition of the PDE4 isoenzyme in lung cells,
roflumilast is indicated for the management of chronic obstrtuctive
pulmonary disease (COPD) exacerbations. Treatment with Roflumilast
is associated with an increase in psychiatric adverse reactions,
including suicide and suicidal attempts.
|Characters||White to off-white crystalline powder||Complies|
|Identification||IR:similar to Reference Standard||Complies|
|Appearance of solution||Clear and colorless||Complies|
|Loss on Drying||≤0.5%||0.06%|
- Single Impurity ≤1.0%
- Sum of Impurity≤2.0%
|Assay(Anhydrous)||98.0% to 101.5%||100.2%|
Roflumilast can be used for the prevention and treatment of
respiratory disease, and used for the treatment of severe chronic
obstructive pulmonary disease (COPD) and excessive mucus cough
bronchitis, asthmatic bronchitis, bronchial asthma, respiratory
tract associated with abnormal secretion of acute and chronic
bronchitis, air sacculitis, etc.
Chronic obstructive pulmonary disease (referred to as "COPD"), is
chronic lung disease that characterized by incompletely reversible
airflow obstruction. It is usually manifested clinically recurrent
cough, sputum, dyspnea and other symptoms. That usually shows
progressive progress features, including the vast majority of
chronic bronchitis and emphysema. As the disease progresses, it
will lead to airway remodeling, and ultimately develop to
irreversible airflow obstruction, or coexist with asthma overlap.
Therefore, improving the control of airflow obstruction and
inflammation is the main goal of drug research at home and abroad.
Chronic obstructive pulmonary disease (COPD) is one of progressive
and life-threatening lung disease and one of the human health
"killer". It makes dyspnea, loss of activity. The disease typically
includes chronic bronchitis and emphysema. It is estimated that
about 210 million people worldwide suffer from the disease, and
COPD will become the third largest cause of death in the world by
2020. Based on the conclusions of the US National Heart, Lung, and
Blood Institute, smoking is the major risk factor for COPD.
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