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S-23 Male Hormonal Sarms Raw Powder Oral CAS: 1010396-29-8 For Muscle Building

Categories Sarms Raw Powder
Brand Name: TINGYI
Model Number: CAS: 1010396-29-8
Certification: GMP , ISO 9001:2008
Place of Origin: CHINA
MOQ: 10g
Price: Contact Us
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 5000kg/Month
Delivery Time: Usually within 7 work days
Packaging Details: Stealth and discreet packaging
Product Name: S-23
CAS: 1010396-29-8
MF: C18H13ClF4N2O3
MW: 416.75400
Purity: 99.50%
appearance: white crystalline powder
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S-23 Male Hormonal Sarms Raw Powder Oral CAS: 1010396-29-8 For Muscle Building

Male Hormonal SARMs Muscle Building Steroids Oral White Raw Powder S-23 S23 CAS 1010396-29-8 For Bodybuilding


Product Name: S-23

Product Details:



Product Name


S-23

Alias


S23

CAS


1010396-29-8

MF


C18H13ClF4N2O3

MW


416.75400

Purity


99.50%

Dosage


10mg to 15mg

Grade


Pharmaceutical Grade

Appearance


white crystalline powder

Standard


USP
Usage

Male hormonal contraceptive, increase muscle mass, reduce fat


Description:


Developed by GTx, S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate. Additionally, in a study done on rats a dose equivalent to 15 milligrams (mg) for a 180lb male was shown to also increase bone mineral density, as well as promote muscle mass growth and fat loss. Hence, S-23 is versatile in that it can be used for bulking and for cutting. S23 or (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide is a new SARM, which is developed as a possible male hormonal contraceptive. It links to the androgen receptor (AR) more intensely (with a Ki of 1.7nM) as compared to older medicines such as Andarine.

As of today, what we know is that S23 is an easy-to-dose oral SARM that can boost lean muscle mass growth while being tissue selective at the same time.

Sarms S23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.


A 2009 study performed on rats showed potential for S-23 to be used as a male contraceptive. In this study, six rats were given a dose of 0.1 mg per day for 10 weeks. As a result, both LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone) levels decreased. These effects were statistically significant, since four of the six rats had no sperm in the testis. What’s more, none of the rats was able to impregnate a female rat during mating trials. However, this contraceptive effect was temporary – after just 100 days from last dose the infertility was reversed, and there was a 100% pregnancy rate.

A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM.

The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.


Application:


S-23 not only boosted muscle mass, but also reduced fat mass, as studied. SARMs have a bit of a 'soft' image in the doping world. They don't stimulate muscle growth in the way that anabolic steroids do, but many users say that they are safer. There are no studies yet that confirm this suspicion. But that S23 is not one of the safer SARMs - we'd be willing to wager a bottle of BCAAs on that.


S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23.

GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions.

GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.


Function:


S-23 not only boosted muscle mass, but also reduced fat mass, as studied. SARMs have a bit of a 'soft' image in the doping world. They don't stimulate muscle growth in the way that anabolic steroids do, but many users say that they are safer.

There are no studies yet that confirm this suspicion. But that S23 is not one of the safer SARMs - we'd be willing to wager a bottle of BCAAs on that. S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23.


Dosage:


Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective. Nonetheless, this is not recommended because there have not been studies done on humans to replicate the contraceptive effect shown in rats.



OUR ADWANTAGE:


1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.


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Product Tags:

raw steroid powders

  

sarms steroids

  
Quality S-23 Male Hormonal Sarms Raw Powder Oral CAS: 1010396-29-8 For Muscle Building for sale
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