Supply 99% Bulking Cycle Weight Loss Steroids L-Carnitine Raw
Powder CAS 541-15-1
Appearance: White crystalline powder
Melting Point: 210 - 212 °C
Solubility: 2500 g/L (20 °C)
Alpha:-31 º (c=10, H2O)
Storage Temperature: 2-8°C
Refractive index: -32 ° (C=1, H2O)
Export Markets: Global
L-carnitine occurrs mainly in red meat (beef, lamb), in small
amounts also in white meat (chicken, turkey).Only very small
quantities are found in vegetarian foods. Vegetarians and Vegans
thus usually have very low L-carnitine levels.It is most sensible
as a food supplement for people, who are mentally and physically
very active, on a diet or vegetarians.
It is transparent or white crystalline powder, m.p. 200 ℃
(decomposition). It is easily soluble in water, alkaline, methanol
and ethanol but nearly insoluble in acetone and acetate and
insoluble in chloroform. It is hygroscopicity. Rabbit: oral LD50:
2272-2444mg/kg, ADI 20mg / kg.
Application and prospect of functional food
L-carnitine, as a new kind of nutritional supplements, especially
as the additive of baby formula, athlete food, and food for losing
weight and bodybuilding, has been currently widely applied in
functional foods. The commercialized L-carnitine is mainly its
hydrochloric acid salt, tartaric acid salt and citric acid
1. Application in infant formula food
L-carnitine plays an important role in the baby’s metabolism
process of taking fat as a source of energy. Owing to that the weak
ability of baby of de no biosynthesis of L-carnitine can’t meet the
demands of its normal metabolism, it must be ingested exogenous
L-carnitine base in order to ensure the best in body fat oxidation
state and provide enough energy to maintain normal body temperature
of the baby. In addition, L-carnitine also has certain effects on
boosting infant growth and development and improving metabolic
balance. So it is necessary to strengthen the L-carnitine in infant
food, especially in soy-based infant formula. Because of the low
carnitine content in soy, the limit of L-carnitine content in
infant formula food is 70 ~ 90mg/kg in China. Now China has
carnitine fortified infant formula milk that has entered into
2. Application of athletes Food
Decombaz J. et al have reported that after fierce exercise, the
free carnitine content in human muscle tissue will decrease by 20%
and the supplemental of carnitine can alleviate the fatigue of the
body because L-carnitine can promote fat oxidation of the body as
well as provide sufficient energy which is good for the sports
endurance as well as explosiveness improvement. If L-carnitine is
used in combination with octacosanol, then the effect of improving
the body strength would be multiplied, manifested as the systemic
muscles relaxation, improved explosive power and endurance, and
increased basal metabolic rate as well as improved nutritional
status of the myocardium. Commonly used method is to add
L-carnitine to athletes’ beverage.
3. Application in the food for losing weight
In the early 70s, there had been patent reported of using DL-
carnitine for the prevention and treatment of obesity.
Subsequently, because of the negative effect, DL-carnitine was
replaced by L-carnitine. Practice has proved that L-carnitine
fortified food has good effect on treating the fat metabolism
disorder caused by carnitine deficiency in vivo. It can prevent
obesity and fatty liver due to the accumulation of lipids in the
liver and muscle fibers. Kuwata thought that obesity patients due
to lack of exercise have large amount of accumulated fat and have
low carnitine biosynthesis capability. Through ingestion of
L-carnitine, they can effectively convert excess body fat into
energy to be released, thus playing a role in prevention and
treatment of obesity. Thereby the lipid-lowering food with
L-carnitine as the main component becomes very popular in the
1. L-carnitine is a dietary supplement newly approved by China. It
is mainly used to strengthen the soy-based baby food and promote
the absorption and utilization of fat. D- and DL-type have no
nutritional value. China states: it can be used in biscuits,
drinking fluids and milk drinks with usage amount of 600 ~ 3000mg /
kg; for solid drink, drinking liquid and capsules, the amount
should be 250 ~ 600mg/kg; the amount of milk powder is 300 ~ 400mg
/ kg; the amount of use in infant formula is 70 ~ 90mg/kg (in terms
of L- carnitine, 1g equivalent 0.68g L- carnitine tartrate).
2. Used in pharmaceutical, nutrient health food, functional
beverages, and feed additives.
3. Used as appetite enhancers.
4. Antimethemoglobinemic, cyanide antidote
5. Essential cofactor of fatty acid metabolism; required for the
transport of fatty acids through the inner mitochondrial membrane.
Synthetized primarily in the liver and kidney; highest
concentrations f ound in heart and skeletal muscle. Dietary sources
include red meat, dairy products, beans, avocado.
6. Carniking(R) is a product for premix- and feed industry. It is
particularly recommended for the enrichment of compound feed.
7. L-Carnitine is a natural, vitamin-like nutrient wich plays an
important role inhuman metabolism. It is essential in the
utilization of fatty acids and in transporting metabolic energy.
8. Natrulon(R) RC-100 is 100% L-Carnitine. This white crystalline
powder, highly hygroscopic and amino acid like material brings not
only the exfoliation but also, an additional benefit of a high
level of moisturization capability.
9. Natrulon(R) RC-50DG is a 50% solution of L-Carnitine in
decaglycerol/water. Natrulon(R) RC-50DG to provide a truly
multi-functional product: an exfoliating product with excellent
1. Extraction L-carnitine is naturally presented in meat and dairy
so they can be extracted directly from L- carnitine containing beef
and cow's milk. Reported in the literature, 0.6 g crystallize
carnitine can be extracted from 450g beef extract; 100 g of 2% L
carnitine-containing lactose powder can be extracted from 56kg cow
milk. However, the cost of extraction method is high which is
economically not reasonable.
2. Microbial fermentation Research shows that there are also many
kinds of microorganisms containing L- carnitine. Use yeast,
Aspergillus, Penicillium, Rhizopus and other microorganisms for
submerged culture or solid state fermentation can accumulate L-
carnitine. But because the screening work of strains is very
complicated, the current fermentation level is relatively low. It
was reported using 2% DL- carnitine as the raw material, after 44 h
of fermentation at 25, yields a 0.4% accumulated L- carnitine.
3. Synthesis Since 1953, there have been foreign patents about DL-
carnitine synthesis report. Industrial production had emerged since
1960s. In 1982, there were also domestic production and application
as stomach drugs in China. Starting from DL- carnitine, use camphor
acid, N- acetyl -D-ethylbenzene or glutamic acid -L - (+) tartaric
acid as resolving agent, generate L-carnitine through chemically
split. But the racemization of carnitine is very difficult and
can’t be recycled. The industrial production still demands new
4. Enzymatic conversion This is the most studied and most promising
method. We can first apply chemically synthesized DL-carnitine for
acetylation into amide or nitrile which then subject to selective
hydrolysis resolution using enzymes derived from microorganisms.
For example, Zhongshan Qing et al have used lactamase derived from
Pseudomonas microorganisms for selective hydrolysis DL-carnitine
amide or carnitine nitrile and obtain L-carnitine with optical
purity being over 99%. In addition, we can also apply enzymatic
conversion using β- dehydrogenation carnitine, enzymatic hydrolysis
of trans-crotonobetaine and enzymatic hydroxylation of γ- butyl
betaine for preparing L- carnitine. Currently, only Switzerland,
Italy, and Japan have applied this method. Enzymatic conversion is
also being studied in Jiangsu Institute of microbes.
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