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Construction material thickener HPMC(Hydroxypropyl Methyl Cellulose) 9004-65-3

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Construction material thickener HPMC(Hydroxypropyl Methyl Cellulose) 9004-65-3

Construction material thickener HPMC(Hydroxypropyl Methyl Cellulose) 9004-65-3

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1、Product Introduction The product is nonionic cellulose ether, white powder in appearance, odorless and tasteless. It is soluble in water and most polar organic solvents, and sells into transparent or slightly turbid colloidal solution in cold water. The aqueous solution possesses such...

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Product Details

Hydroxypropyl Methyl Cellulose ( HPMC, MHPC )

Hydroxypropyl Methyl Cellulose is a multi-purpose medicinal materials, can be used as thickener, dispersant, emulsifier and film-forming agent. Made in the drug tablet film coating, adhesive, can significantly improve the dissolution rate of drugs can enhance the waterproof tablets. Also as a suspension, ophthalmic preparations, controlled release formulations such as skeletons and floating tablets.

HPMC and other synthetic polymers and colloidal drug binding, can prevent water and alcohol drugs from the transparent gel to separate the water and improve water retention, is also being food, cosmetics and other areas used as a thickener, emulsifier and improve Rheological properties, as well as to other daily-use chemical industry, etc.

Currently this product has become the main material for plant capsule.

1、Product Introduction

Common Name

Hydroxypropyl Methylcellulose

Abbreviation

HPMC

9004-65-3

9004-34-6

Approval certificate

Lu Yao Zhun Zi F2012001

Conforming Standard

CP (Chinese Pharmacopoeia)
USP (United States Pharmacopoeia)
EP (European Pharmacopoeia)
JP (Japanese Pharmacopoeia)

The product is nonionic cellulose ether, white powder in appearance, odorless and tasteless. It is soluble in water and most polar organic solvents, and sells into transparent or slightly turbid colloidal solution in cold water. The aqueous solution possesses such characteristics as surface activity, high transparency and stable performance. It also owns the property of thermal gelling, thus its aqueous solution can form into glue to separate out after heating, and then it dissolve after cooling, with different gelling temperature in different specifications of products. The solubility changes with viscosity. The lower viscosity is, the larger solubility is. The properties of HMPC of different specifications are different, while solution of HPMC in water will not be affected by PH value.
2、Product Application
In oral preparation, HPMC is mainly applied as tablet adhesive, film coating material and framework material of sustained-release; in topical preparation, it is mainly applied as suspending agent and thickener of ophthalmology preparation, and also as emulsifier, suspensions and stabilizer of gel and ointment.
3.Technical Index


Item

Specification

60GD(2910)

65GD(2906)

75GD(2208)

Methoxy group%

28.0-32.0

27.0-30.0

19.0-24.0

Hydroxypropyl group%

7.0-12.0

4.0-7.5

4.0-12.0

Gelation temperature℃

56-64

62.0-68.0

70.0-90.0

Viscositympas

3,5,6,15,50,4000

50,4000

100,4000,15000,100000

Loss on drying%

≤5.0

Residue on ignition%

≤1.5

pH

4.0-8.0

Heavy Metal

≤20

Arsenic (As)

≤2.0

Explanation:
1. The viscosity in USP is 80%-120% when the marked viscosity equals to or is lower than 100mpas, while 75%-140% when the marked viscosity exceeds 100mpas.
2. The viscosity in EP is 80%-120% when the marked viscosity is lower than 600mpas, while 75%-140% when the marked visc

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